Modern ideas about the etiology, pathogenesis, diagnosis and treatment of chronic nonspecific cervicitis

Currently, cervicitis of nonspecific etiology is one the urgent problems modern gynecology due to extremely high frequency their occurrence, a tendency chronic relapsing course, negative impact on reproductive health, and risk developing number complications. The role violations vaginal microbiocenosis local immune status in development CNC has been convincingly shown. replacement lactobacilli with predominantly anaerobic microorganisms (Ureaplasma, Mycoplasma, Gardnerella vaginalis, Prevotella, Peptostreptococcus spp. Bacteroides spp.), characteristic bacterial vaginosis, often detected patients CNC. Of particular importance from point view clarifying pathophysiological mechanisms new diagnostic prognostic markers, as well personalization therapy, study cytokine status. Cervicitis other inflammatory diseases lower genital tract are characterized by an increase expression pro-inflammatory cytokines simultaneous inhibition formation anti-inflammatory cytokines. Significant multidirectional changes balance pro- were revealed active sluggish cervicitis. It should be noted that, despite variety proposed approaches this problem still far being solved date. One promising directions therapy based molecular genetic markers (polymorphisms genes, Toll-like receptors, genes detoxification system). use such personalized approach can significantly effectiveness treatment reduce disease recurrence.